UV-Induced Tetrazole-Thiol Reaction for Polymer Conjugation and Surface Functionalization

UV-Induced Tetrazole-Thiol Reaction for Polymer Conjugation and Surface Functionalization.

A UV-induced 1,3-dipolar nucleophilic addition of tetrazoles to thiols is described. Under UV irradiation the reaction proceeds rapidly at room temperature, with high yields, without a catalyst, and in both polar protic and aprotic solvents, including water. This UV-induced tetrazole-thiol reaction was successfully applied for the synthesis of small molecules, protein modification, and rapid an...

Gold Solid Surface Thiol Oligo Conjugation

Functionalization of Polymer Nanoparticles by Thiol-Ene Addition

Syndiotactic 1,2 polybutadiene nanoparticles (volume average diameter 13 nm) were func tionalized in aqueous dispersion by free radical mercaptan addition. By appropriate choice of both water soluble radical initiator andmercaptan concentration, nanoparticles with a degree of functionalization of up to 85% were prepared using 3 mercaptopropionic acid methyl ester and 3 mercaptopropionic acid. O...

Giant enhancement in UV response of ZnO nanobelts by polymer surface-functionalization.

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Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation.

Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for c...